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Mechanism of proton delivery in ascorbate peroxidase

Reference	BB/C00602X/1
Principal Investigator / Supervisor	Professor Emma Raven
Co-Investigators / Co-Supervisors	Professor Peter Moody
Institution	University of Leicester
Department	Chemistry
Funding type	Research
Value (£)	225,200
Status	Completed
Type	Research Grant
Start date	19/09/2005
End date	18/09/2008
Duration	36 months

Abstract

The aim of this work is to obtain detailed molecular information on the mechanism of proton delivery in ascorbate peroxidase. The specific objectives are: (i) to dissect the detailed mechanism of proton delivery in ascorbate peroxidase: (ii) to elucidate the individual roles of key active residues and the heme propionate in the proton transfer process. To deliver our objectives, we propose an integrated experimental approach that uses the combined power of kinetic and protein engineering techniques, together with high-resolution protein crystallography. The programme has been designed to be relevant across the peroxidase family and will allow us to make important connections between different peroxidases in a way that has not been previously possible.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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