Award details

Absorption and metabolism of flavonoids and hydroxycinnamates: interactions with other dietary components

Reference	BB/C003802/1
Principal Investigator / Supervisor	Professor Alan Crozier
Co-Investigators / Co-Supervisors	Professor Christine Edwards
Institution	University of Glasgow
Department	School of Life Sciences
Funding type	Research
Value (£)	221,966
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	31/08/2007
Duration	36 months

Abstract

Foods rich in antioxidants are believed to reduce risk of heart disease and cancer. The most potent antioxidants are phenolic compounds such flavonoids and hydroxycinnamates found in a wide range of fruits and vegetables as well as in plant derived drinks such as tea, coffee and red wine. Little is known about the factors that influence the bioavailability and in vivo antioxidant potency of these compounds. Some studies have suggested that combining milk with chocolate or tea significantly decreases their effects on plasma antioxidant status and there are indications, albeit very preliminary, that consumption of bread with either chocolate or strawberries may result in enhanced absorption of antioxidant phenolics. In this study, the effects of combining oranges with yoghurt, strawberries with cream, coffee with low and high fat milk, onions with bread and beans with soup with be studied with respect to their antioxidant properties in vitro, gastric emptying and small bowel transit, the appearance of key flavonoids and hydroxycinnamates and metabolites in plasma and urine and their impact on the plasma antioxidant capacity of human subjects. These particular produce have been chosen because they contain high levels of the main dietary phenolics and because the food combinations are common in the UK diet. The results will help provide more effective dietary guidelines and food formulations.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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