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Towards a unified view of substrate binding in the heme peroxidases
Reference
BB/C001184/1
Principal Investigator / Supervisor
Professor Emma Raven
Co-Investigators /
Co-Supervisors
Professor Peter Moody
Institution
University of Leicester
Department
Chemistry
Funding type
Research
Value (£)
229,638
Status
Completed
Type
Research Grant
Start date
01/06/2005
End date
31/05/2008
Duration
36 months
Abstract
The aim of this work is to provide a unified view of substrate binding and electron delivery in the class I heme peroxidase enzymes that is relevant across the whole peroxidase family. To achieve this, we have set a number of objectives that will allow us to make important connections between different peroxidases and that will deliver a level of comparative molecular details that has not been previously possible. The experimental approach will involve redesigning the substrate binding specificity and examining the mechanism of electron delivery in cytochrome c peroxidase, which has been a benchmark for our understanding of heme enzyme catalysis. The combined power of kinetic, spectroscopic and redox techniques, together with protein engineering and X-ray crystallography, will be used.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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