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Selective gene delivery to the vasculature using peptide-modified adenoviral vectors

Reference	BB/C000048/1
Principal Investigator / Supervisor	Professor Andrew Baker
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	Inst of Cardiovascular &Medical Sci
Funding type	Research
Value (£)	205,228
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

Delivery of therapeutic agents site-specifically in vivo holds promise for treatment of diverse pathologies using both drug and gene-based therapies. We aim to achieve target selectivity using adenoviral vector mutants that are devoid of hepatic tropism in vivo combined with small (7-mer) targeting peptides that have been isolated by in vivo phage display. This panel of peptides mediate selective targetting to either brain, heart, kidneys or lung. We will engineer each peptide-modified virus and characterise its biodistribution and infectivity profile in vivo using real time PCR and immunodetection. In addition we will use a combined transductional/bioinformatics approach to isolate the receptor targeted by each peptide. Together, these studies will broaden the scope of gene therapy through modulation of delivery in vivo.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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