BBSRC Portfolio Analyser
Award details
Capuring protein functional information from structural data: 3D templates and genome annotation
Reference
BB/B500031/1
Principal Investigator / Supervisor
Professor Janet Thornton
Co-Investigators /
Co-Supervisors
Institution
EMBL - European Bioinformatics Institute
Department
Finance Officer
Funding type
Research
Value (£)
397,609
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/09/2006
Duration
42 months
Abstract
The aim of this proposal is to improve the assignment of function to genome sequence data. This will be approached by developing novel computational methods and data resources, based on structural data, that will then be linked to expression and proteome data to extend assignments from biochemical function (in vitro) to biological function (in vivo). To fulfil this aim we have set the following objectives: establish, automate and maintain a database of functional sites and 3D templates in enzymes, derived from structural data; analyse enzyme active sites, including their structure and evolution; develop new methods to use this information to help in genome and 3D structure annotation and pathway analysis; develop tools to predict biological function by linking structural data to expression and proteome data. This project has clear applications in the pharmaceutical, agrochemical and biotechnology industries for target discovery, diagnostics, lead identification and drug design.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme
X – not Funded via a specific Funding Scheme
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