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Unravelling how over expression of the HAP4 gene operates to extend life span in yeast

ReferenceBB/A50027X/1
Principal Investigator / Supervisor Professor Peter William Piper
Co-Investigators /
Co-Supervisors
Institution University of Sheffield
DepartmentMolecular Biology and Biotechnology
Funding typeResearch
Value (£) 153,954
StatusCompleted
TypeResearch Grant
Start date 01/02/2004
End date 31/07/2006
Duration30 months

Abstract

Our recent data indicates a correlation between the replicative life spans of respirofermentative yeast cells and the levels of respiration in these cells. This study will establish whether this reflects the influences of respiration over redox balance and the Sir2 NAD plus- dependent histone deacetylase. Activity of the latter enzyme is known to slow yeast ageing by suppressing recombination within the repeated ribosomal DNA (rDNA). The degree to which increased mitochondrial respiratory chain activity can slow rDNA recombination, as well as the pro- apoptotic events in old mother cells, will be determined to distinguish whether senescence arises predominantly by genetic instability or proapoptotic events.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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