Award details

Unravelling how over expression of the HAP4 gene operates to extend life span in yeast

Reference	BB/A50027X/1
Principal Investigator / Supervisor	Professor Peter William Piper
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	153,954
Status	Completed
Type	Research Grant
Start date	01/02/2004
End date	31/07/2006
Duration	30 months

Abstract

Our recent data indicates a correlation between the replicative life spans of respirofermentative yeast cells and the levels of respiration in these cells. This study will establish whether this reflects the influences of respiration over redox balance and the Sir2 NAD plus- dependent histone deacetylase. Activity of the latter enzyme is known to slow yeast ageing by suppressing recombination within the repeated ribosomal DNA (rDNA). The degree to which increased mitochondrial respiratory chain activity can slow rDNA recombination, as well as the pro- apoptotic events in old mother cells, will be determined to distinguish whether senescence arises predominantly by genetic instability or proapoptotic events.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G17849 Unravelling how overexpression of the HAP4 gene operates to extend life span in yeast

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