Award details

Exploiting herparan sulfates for directed neural differentiation of stem cells

Reference	BB/A50007X/1
Principal Investigator / Supervisor	Professor Jeremy Turnbull
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	157,833
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	31/03/2006
Duration	30 months

Abstract

New methods for expansion and differentiation of embryonic stem (ES) cells are essential for realisation of cell-based therapies. Sulfated saccharide motifs in heparan sulfate (HS) confer specific regulatory properties for proteins including many growth factors which control ES cell growth and differentiation. We propose to study the ability of HS saccharides to modulate ES cell proliferation and differentiation into neural lineages. We will also define the HS molecular phenotype of multipotent ES cells and their differentiated variants. These studies will yield new information on the functions of HS in development and generate novel approaches for controlling cell growth and differentiation in stem cell and tissue engineering.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

C18993 Exploiting heparan sulfates for directed neural differentiation of stem cells

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