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Award details
Receptor interaction and oligermerisation of epsilon toxin from C. perfringens
Reference
B20251
Principal Investigator / Supervisor
Professor David Moss
Co-Investigators /
Co-Supervisors
Mr Ambrose Cole
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
215,405
Status
Completed
Type
Research Grant
Start date
13/08/2003
End date
12/11/2006
Duration
39 months
Abstract
Clostridium perfringens epsilon toxin is a pore forming toxin that causes an often fatal form of enterotoxaemia in livestock. Recently, we have determined the structure of this protein in its proto form and would like to continue our investigation into its mode of action. To carry this out we would like to crystallise the active form of this protein as well as investigate its possible interactions with GPI-anchored proteins. Alongside this we would also attempt to produce protein as a heptamer to carry out structural studies using both X-ray crystallographic techniques and electron microscopy on the protein in its pore form.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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