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Artificial signal transduction

Reference	B20170
Principal Investigator / Supervisor	Professor Christopher Hunter
Co-Investigators / Co-Supervisors	Professor Nicholas Williams
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	183,420
Status	Completed
Type	Research Grant
Start date	01/12/2003
End date	31/05/2007
Duration	42 months

Abstract

We have recently developed the first synthetic transmembrane signalling system that can respond to a reagent on one side of a lipid membrane by releasing a different molecule on the other side without having to transport a chemical species across the bilayer. We will modify this vesicle based system so that it can respond to a non-covalent binding event with a target messenger molecule (initially DNA duplex formation). Concurrently, we will modify the response by exploiting enzymatic catalysis, so that the signal on the interior of a vesicle is amplified. Combining these features will yield vesicles that can respond to our choice of targets by providing an amplified optical signal or release of a chemical (unrelated to the target messenger properties). These will be the building blocks of future integrated multicomponent molecular machines.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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