Award details

Structural studies of Bluetongue virus polymerase complex

Reference	B20127
Principal Investigator / Supervisor	Professor Polly Roy
Co-Investigators / Co-Supervisors	Professor David Stuart
Institution	London Sch of Hygiene and Trop Medicine
Department	Infectious and Tropical Diseases
Funding type	Research
Value (£)	411,189
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	30/06/2007
Duration	39 months

Abstract

One of the key challenges in molecular biology is to understand the relationships of proteins in complex structures. Such studies are important for both the particular entities and to illustrate the fundamental principles that govern macromolecular assemblages. Bluetongue Virus core is one of the largest structures solved to date. However, it was not possible to delineate the organisation of the internal enzymatic proteins due to the complexity of the intact particle. The structures of these are critical to further our understanding of the molecular basis for transcription of the Bluetongue Virus and related viruses. The aims of this proposal are therefore to produce 3D structures of individual, and combinations of, polymerase complex proteins and use these for structure-based molecular analyses.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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