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Structural studies of type II polyketide synthases and related proteins

Reference	B20055
Principal Investigator / Supervisor	Professor Thomas Simpson
Co-Investigators / Co-Supervisors	Professor Russell Cox, Dr John Crosby, Professor Matthew Crump
Institution	University of Bristol
Department	Chemistry
Funding type	Research
Value (£)	394,757
Status	Completed
Type	Research Grant
Start date	02/02/2004
End date	01/06/2007
Duration	40 months

Abstract

By studying the actinorhodin synthase from Streptomyces coelicolor we aim to determine how Type II PKS components combine to form a functional complex. We will elucidate the overall 3D architecture of the minimal system, determine how the components recognise one another, and also identify how they bind and stabilise assembly intermediates. Structures of downstream proteins involved in reduction, cyclisation and aromatisation along with their interactions with the minimal PKS components will also be studied.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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