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Molecular investigation of nisin/lipid II complexes: a novel mechanism of membrane recognition for antibiotic design
Reference
B20039
Principal Investigator / Supervisor
Dr Boyan Bonev
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
186,046
Status
Completed
Type
Research Grant
Start date
01/02/2004
End date
31/01/2007
Duration
36 months
Abstract
Resistance to antibiotics is a major problem in the control of pathogenic bacteria. Penicillin tolerance is common and vacomycin resistance has been reported. An alternative exists in the antibiotic nisin, a potent bactericidal peptide. During bactericidal membrane recognition nisin targets peptidoglycan intermediate Lipid II located in the outer leaflet, where the two form lytic oligomeric complexes. We have observed such complexes using solid state NMR and propose a detailed structural study of the nisin/Lipid II complexes using solid state NMR and neutron reflectivity. The structure of Lipid II in the complex will be used as a new template for the design of highly selective antibiotics. Nisin is proposed as the archetype of this new class.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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