BBSRC Portfolio Analyser
Award details
Targeting anisomycin receptors: a chemical biology approach
Reference
B20011
Principal Investigator / Supervisor
Professor Alison Hulme
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
124,114
Status
Completed
Type
Research Grant
Start date
01/02/2004
End date
31/01/2006
Duration
24 months
Abstract
The precise target of action of the pyrrolidine antibiotic anisomycin which activates the mitogen-activated protein (MAP) JNK and p38 stress kinase (SAPK) pathways in mammalian, yeast, or insect cells has not been elucidated. As biochemical and genetic studies demonstrate that the SAPK pathways regulate cell proliferation, differentiation and cell repair/apoptosis, studies into the mechanism of initiation and regulation of these pathways may provide new leads for therapeutic targets. the chemical synthesis of biotinylated molecular probes and photoactivatable molecular probes based on recent anisomycin analogues should allow the future isolation of the anisomycin receptor and produce information relating to targets upstream of the MAPKKs.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search