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Assembly of multi-drug transport proteins; a fundamental aspect of antibiotic resistance of pathogenic bacteria
Reference
B19845
Principal Investigator / Supervisor
Professor Paula Booth
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
195,028
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
The resistance of pathogenic bacteria to antibiotics is a major worldwide problem. Bacterial efflux pumps are a main cause of this antibiotic resistance. These are membrane proteins that act as multi-drug transporters and pump a wide variety of antibiotics out of bacterial cells, and quickly adapt to recognise new antibiotics. We propose to study the folding and assembly of the family of small multi-drug transport proteins (SMRs), focusing on the proteins from Escherichia coli (EmrE), Mycobacterium tuberculosis (TBsmr) and Pseudomonas aeruginosa (PAsmr). Understanding how they fold to recognise a diverse array of drugs is crucial to understanding their multi-drug function, as well as for future studies designing effective inhibitors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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