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Theoretical methods for characterising proton-electron coupling in membrane protein structures
Reference
B19813
Principal Investigator / Supervisor
Dr James Warwicker
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
155,425
Status
Completed
Type
Research Grant
Start date
01/01/2004
End date
31/12/2006
Duration
36 months
Abstract
Advances in membrane protein structure determination bring fresh impetus to the study of coupled proton and electron transport. Calculations of protein-induced changes in proton and electron affinities, with a semi-macroscopic model, are relatively scarce for membrane proteins. Current indications are that an accurate model for these tightly-coupled charge systems will need to include sidechain re-arrangement over different protonation/redox states. The new model will be tested against known wild-type/mutant delta pKas in bacteriorhodopsin, as well as protonation vs redox state data for cyt c oxidase and photosynthetic reaction centre. Energy transduction mechanisms in other systems will be probed, and programs will be made freely available.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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