BBSRC Portfolio Analyser
Award details
Structural characterisation of complexes that arise as intermediates during the repair of general DNA damage
Reference
B19728
Principal Investigator / Supervisor
Dr Tracey Barrett
Co-Investigators /
Co-Supervisors
Dr Simona Ceschini
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
150,377
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
31/08/2005
Duration
24 months
Abstract
The repair of DNA damage, a vital cellular process, is performed by a number of distinct mechanisms that can be broadly categorised by their affinity for specific or non-specific lesions. Whilst a plethora of structural data exists for the specific class including complexes, there is only one example of a general DNA repair protein bound to its target. We aim to: (1) determine the structure of a key component of the UvrABC pathway bound to several distinct forms of DNA damage based on our recent structural data (unpublished); (2) the structure determination of complexes involved in the incision process; and (3) the characterisation of protein:DNA complexes involving the general DNA repair enzyme UVDE.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search