Award details

Solution structure and behaviour of proteins from Raman Optical Activity

Reference	B19720
Principal Investigator / Supervisor	Professor Laurence Barron
Co-Investigators / Co-Supervisors	Dr Lutz Hecht, Professor Neil William Isaacs
Institution	University of Glasgow
Department	School of Chemistry
Funding type	Research
Value (£)	176,739
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

Approximately 100 proteins representing the most highly populated folds will be prepared and their ROA spectra measured, together with many proteins and viruses from outside sources, to create a large database from which information about the aqueous solution structures of proteins, including the coat proteins of intact viruses, may be deduced using pattern recognition methods. The many structure-sensitive bands in protein ROA spectra will provide information about the fold itself in addition to secondary structure class. Information about conformational elements present in natively unfolded proteins will also be obtained, as well as conformations of aromatic side chains. The application of ROA to membrane proteins will be explored.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search