Award details

Structural basis of antibiotic resistance

Reference	B19490
Principal Investigator / Supervisor	Professor James Naismith
Co-Investigators / Co-Supervisors	Professor Ian Booth
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	205,848
Status	Completed
Type	Research Grant
Start date	15/09/2003
End date	14/09/2006
Duration	36 months

Abstract

Resistance to antibiotics is of concern in both human and animal medicine. Resistance comes from either by mutating a drugs target, destroying the drug, pumping out the drug from the bacteria or by preventing its ingress. From samples taken from a patient there is a unique opportunity to study how mutations in the outer membrane protein C (ompC) gene of E.coli has conferred tolerance to antibiotics. The resistance profile of subpopulations of the bacterial infection and this has been correlated with changes in ompC. We have expressed, purified, crystallised and obtained diffraction from crystals of one mutant of ompC. This proposal seeks funding to determine the structure of several mutants and to correlate this altered membrane porosity.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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