Award details

Structure and power stroke of dynein molecules

Reference	B19478
Principal Investigator / Supervisor	Professor Peter Knight
Co-Investigators / Co-Supervisors	Dr Stanley Alan Burgess
Institution	University of Leeds
Department	Institute of Membrane & Systems Biology
Funding type	Research
Value (£)	271,928
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

Dyneins are protein motors crucial to many essential cellular functions such as beating of the sperm tail flagellum. However their molecular structures and mechanisms of force generation are poorly known. We will determine the structure of purified flagellar dynein molecules by electron microscopy and image processing. Specific nucleotide conditions will be used to discover the shape changes driven by ATP hydrolysis. We will also examine dynein structure in the flagellum by electron microscopy. The molecular structure of the isolated dynein will allow interpretation of the more complex morphology of the intact machine, and thus produce insights into the general mechanism of action of this family of motors.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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