BBSRC Portfolio Analyser
Award details
Structural studies of the transmembrane proteins Phospholemman and ErbB-2
Reference
B19450
Principal Investigator / Supervisor
Dr Andreas Kukol
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
189,484
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
31/08/2006
Duration
36 months
Abstract
Recently developed infrared spectroscopic techniques, based on specific labelling, enables the determination of orientation and interaction of transmembrane helices. In combination with molecular modelling detailed structural models of transmembrane helical bundles can be obtained. Incorporating novel developments, this technique will be employed to study Phospholemman, a cardiac ion channel and the transmembrane domain of the mutant oncogenic ErbB-2 receptor. The potential results of this project will enhance our understanding of transmembrane protein structure and also provide valuable basic knowledge towards understanding the mechanisms of heart diseases in the case of phospholemman and breast cancer in the case of ErbB-2.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search