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Novel inhibitors as probes for the molecular biology of O-glycosylated proteins
Reference
B19303
Principal Investigator / Supervisor
Professor Timothy Gallagher
Co-Investigators /
Co-Supervisors
Dr Anthony Corfield
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
298,424
Status
Completed
Type
Research Grant
Start date
01/12/2003
End date
31/03/2007
Duration
40 months
Abstract
O-Glycosylated proteins are responsible for essential cell functions and at mucosal surfaces for the innate barrier protection against the external environment. They are formed through well- characterised pathways in all cells and are defective in colorectal cancer. Selective manipulation of these processes will advance significantly our knowledge of their overall importance to the normal cell and facilitate intervention in defined disease aberrations. Inhibition of these pathways has been achieved using O-benzyl GalNAc but no other compounds have been tested. The synthesis of a family of novel analogues will enable selective manipulation of biologically critical O-glycosylation pathways to be achieved.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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