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The mechanism of coupled and catalytic electron and proton transfers in flavocytochrome C3 - a model oxidoreductase
Reference
B19096
Principal Investigator / Supervisor
Professor Fraser Armstrong
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Oxford Chemistry
Funding type
Research
Value (£)
192,472
Status
Completed
Type
Research Grant
Start date
04/08/2003
End date
03/08/2006
Duration
36 months
Abstract
Flavocytochrome c3, a soluble fumarate reductase, presents outstanding opportunities to resolve important issues in biological redox catalysis. This arises from a unique combination of factors: 1) the exquisite voltammetry it displays when bound on a graphite electrode, enabling us to observe the FAD and four heme groups and control and measure their reactions; 2) high-resolution x-ray structures; and 3) highly successful molecular biology. We will achieve a detailed picture of how the various catalytic tasks taking place at different centres across the enzyme are coupled and coordinated, and of the physical and molecular mechanisms by which electrons and protons are relayed through an enzyme.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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