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Award details
Classification of protein-ligand interactions sites and screening for binding sites in proteins of unknown function
Reference
B18760
Principal Investigator / Supervisor
Dr Richard Jackson
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
168,664
Status
Completed
Type
Research Grant
Start date
14/04/2003
End date
14/04/2006
Duration
36 months
Abstract
With the recent growth in protein structure a wealth of information is becoming available about proteins and their interactions with small ligands (substrates, cofactors, drugs). This proposal seeks to classify protein-ligand interactions using a fast similarity matching method called geometric hashing. Many proteins interact through similar modes even though the proteins do not have significant sequence similarity or share the same 3D fold. We will classify protein-binding sites based on their local 3D atomic similarity (as opposed to existing databases that classify according to sequence or 3D fold similarity). This will also allow screening for new binding sites in structurally determined proteins of yet unknown function.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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