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Computational analysis of nucleosome positioning
Reference
B18708
Principal Investigator / Supervisor
Professor Christopher Hunter
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Chemistry
Funding type
Research
Value (£)
178,144
Status
Completed
Type
Research Grant
Start date
01/06/2003
End date
31/05/2006
Duration
36 months
Abstract
We propose to develop a computational method for predicting nucleosome positioning sites on DNA. The proposal builds on a successful programme for predicting the sequence-dependent structure of naked DNA, extending that approach to protein-DNA complexes. The key to the analysis is calculation of the energy required to bend DNA into a nuclesome bound conformation. The size of this structure represents a major challenge, but it is a system for which excellent experimental data is available for validation of the method. Since the nucleosome complex is the substrate for all DNA processing proteins in the nucleus of eukaryotes, the results have potential implications in many different fields.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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