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Structural analysis of eukaryotic initiation factor 4B and its interactions with the polyadenylate binding protein
Reference
B18685
Principal Investigator / Supervisor
Professor Stephen Curry
Co-Investigators /
Co-Supervisors
Professor Steve Matthews
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
200,032
Status
Completed
Type
Research Grant
Start date
26/08/2003
End date
25/08/2006
Duration
36 months
Abstract
Eukaryotic initiation factor 4B (eIF4B) mediates binding of mRNA to the 40S ribosomal subunit during translational initiation and interacts with the polyadenylate binding protein (PABP), thereby increasing the efficiency of re-initiation. We aim (i) to determine the structure of the N-terminal domain of eIF4B which binds PABP and makes sequence-specific interactions with RNA; (ii) to probe the fine details of the RNA binding specificity of eIF4B; (iii) to determine the structure of a complex between the N-terminus of eIF4B and the C-terminal domain of PABP, thus revealing the structural basis of their interaction; (iv) to probe for the presence of structural elements in the C-terminus of eIF4B.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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