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Design and optimisation of a new system for biological electron transfer and energy transduction
Reference
B18667
Principal Investigator / Supervisor
Professor Mike Jones
Co-Investigators /
Co-Supervisors
Ms Marion Wakeham
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
179,900
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/11/2006
Duration
44 months
Abstract
Energy-transducing electron transfer in the purple bacterial reaction centre is strongly asymmetric, despite the presence of two approximately symmetrical transmembrane cofactor branches. In previous studies we have used site-directed mutagenesis to partially activate a new pathway for transmembrane electron transfer along the so-called inactive- or B-branch of cofactors. This work seeks to understand how the efficiency of this new electron transfer reaction can be optimised through a combination of directed mutagenesis, random mutagenesis and forced evolution. The aim is to bring deeper insights into the design of electron transfer pathways in complex redox proteins, and the factors that control the rate of biological electron transfer.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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