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Targetting G-quadruplex DNA through a dynamic combinatorial approach
Reference
B18661
Principal Investigator / Supervisor
Professor Sir Shankar Balasubramanian
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
165,456
Status
Completed
Type
Research Grant
Start date
18/08/2003
End date
17/02/2007
Duration
42 months
Abstract
Quadruplex DNA has emerged as a structure that is likely to have broad importance in the mechanism and regulation of a number of biological processes that include telomere maintenance and cancer proliferation. The quadruplex is therefore a molecular target for molecular probes which may have therapeutic potential. Having identified potential recognition elements of the quadruplex, this proposal aims to apply the principles of dynamic covalent chemistry to template the assembly of binding elements with quadruplex DNA. The main deliverables will be the identification of novel quadruplex-specific ligands and a significant extension of the dynamic chemistry methodology.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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