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The functional significance and control of electron transfer via two separate pathways in photosystem I

Reference	B18658
Principal Investigator / Supervisor	Professor Peter Heathcote
Co-Investigators / Co-Supervisors	Professor M Evans, Professor Saul Purton, Dr Stephen Rigby
Institution	Queen Mary University of London
Department	Sch of Biological and Chemical Sciences
Funding type	Research
Value (£)	227,804
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	30/04/2006
Duration	36 months

Abstract

A spectacular 2.5 Angstrom resolution structure has been determined for the Photosystem I complex of oxygenic photosynthesis. Based upon this structure we have successfully designed and produced site-directed mutants of photosystem I from Chlamydomonas reinhardtii, and in parallel developed spectroscopic methods, to monitor electron transfer and redox cofactor-protein interactions. This work shows that both sides of the PSI reaction centre are active. Spectroscopic analysis of the mutants will now be used to determine the functional role of the two separate pathways, and to elucidate those features of the protein cofactor interactions which engineer the redox potentials of cofactors, and determine the direction and rate of electron transfer.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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