Award details

Nanoparticle-based receptor dimerisation sensor

Reference	B18374
Principal Investigator / Supervisor	Professor David Fernig
Co-Investigators / Co-Supervisors	Professor Mathias Brust, Professor Richard Nichols, Professor David Schiffrin
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	201,708
Status	Completed
Type	Research Grant
Start date	21/05/2003
End date	21/05/2006
Duration	36 months

Abstract

Ligand-induced oligomerisation is a key step in the activation of receptors. Fibroblast growth factors (FGF) possess a dual receptor system consisting of a tyrosine kinase receptor (FGFR) and the heparan sulfate co-receptor. We will develop a nanoparticle probe, coupled to the extracellular, ligand-binding domain of FGFR1 that is anchored in a hybrid bilayer membrane for the analysis of FGF- induced FGFR oligomerisation. By virtue of its physical properties, this probe will allow an extremely sensitive analysis of the FGFR oligomerisation reaction in vitro and eventually in vivo. The methods developed in this proposal will generally be applicable to the study of molecular interactions.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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