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Award details
Novel steroid mimics directed towards the nuclear receptor superfamily
Reference
B18337
Principal Investigator / Supervisor
Professor Nicholas Tomkinson
Co-Investigators /
Co-Supervisors
Institution
Cardiff University
Department
Chemistry
Funding type
Research
Value (£)
155,064
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
14/08/2006
Duration
42 months
Abstract
The aim of this proposal is to explore the design, synthesis and screening of a series of novel steroid mimetics and to increase fundamental understanding of molecular geometry and structure and its relationship with biological activity. Steroid hormones regulate the expression of complex gene programs by binding to members of the nuclear receptor family of ligand-activated transcription factors. An ability to mimic the steroid structure would make an important contribution to this area of medicinal chemistry. Within this work we plan to develop novel molecular scaffolds that mimic the rigid tetracyclic core of steroids whilst greatly simplifying the architectural complexity and hence synthetic chemistry associated with their preparation.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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