Award details

Semi-synthesis and structural analysis of glycoprotein therapeutics

Reference	B18138
Principal Investigator / Supervisor	Dr Derek Macmillan
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Sch of Chemistry
Funding type	Research
Value (£)	148,584
Status	Completed
Type	Research Grant
Start date	24/02/2003
End date	23/09/2005
Duration	31 months

Abstract

Recently, we were first to apply protein semi-synthesis to the assembly of O-linked glycoproteins. We have also developed methods for the solid-phase synthesis of thioether-linked N-glycopeptide mimics as thioesters suitable for a chemoselective chemical reaction known as native chemical ligation. Herein we propose a new strategy for the assembly of N-linked glycoproteins and glycoprotein mimics. This process involves joining small synthetic peptides containing the sugar structure of interest to the remaining portion of the protein backbone, which is purified from bacteria. Study of these products may contribute to our understanding of the role of protein glycosylation and provide a semi-synthetic route to glycoprotein therapeutics.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B18138/2 Semi-synthesis and structural analysis of glycoprotein therapeutics

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