Award details

Proteoglycan-fibrillar collagen interactions in cornea and the role of sulphation

Reference	B18021
Principal Investigator / Supervisor	Professor Andrew Quantock
Co-Investigators / Co-Supervisors	Professor Bruce Caterson
Institution	Cardiff University
Department	Optometry and Vision Sciences
Funding type	Research
Value (£)	281,524
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	31/10/2006
Duration	42 months

Abstract

Proteoglycans are functionally important molecules in the cornea of the eye that interact with collagen fibrils and help maintain proper tissue ultrastructure. The addition of sulphate groups to the corneal proteoglycans is thought by some to have a huge influence on their ability to interact with fibrillar collagen. Abnormal sulphation patterns, the thinking goes, render the proteoglycans unable to associate with collagen fibrils as they would ordinarily do. Also, it is possible that under these situations proteoglycans might self-associate, something they do not appear to do so when normally sulphated. This research will employ a combined biochemical, immunochemical and biophysical approach to try and establish the nature of proteoglycan- collagen and proteoglycan-proteoglycan interactions in cornea and the role of sulphation.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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