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Award details
Modulation of the folding and function of a membrane kinase by the lipid environment
Reference
B18016
Principal Investigator / Supervisor
Professor Paula Booth
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
191,448
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
15/02/2006
Duration
36 months
Abstract
The lipid environment of biological membranes can regulate the activity of integral membrane proteins. An E.coli membrane protein kinase plays a critical role in the response of E.coli to environmental stress, which may result from regulation of the kinase by the lipids. The project will be investigate the role of particular lipid properties in the folding and function of this membrane kinase. A specific focus will be the use of these lipid properties to aid the design of in vitro systems to fold and stabilise functional membrane proteins for biophysical, biochemical and pharmaceutical study. This project will also result in the first molecular level study of the folding kinetics and mechanism of an E.coli integral membrane protein.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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