Award details

Molecular clips for DNA - bimetallic intercalator libraries

Reference	B17969
Principal Investigator / Supervisor	Professor James Thomas
Co-Investigators / Co-Supervisors	Dr Michelle Webb
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	177,232
Status	Completed
Type	Research Grant
Start date	01/08/2003
End date	31/07/2006
Duration	36 months

Abstract

The interaction with duplex DNA of bimetallic octahedral metal complex containing separate intercalation sites (DNA Clips) will be investigated. The electrochemistry and or photochemistry of the isolated complexes will be investigated. Their interaction with DNA will then be explored using a variety of experimental techniques to ascertain binding affinities. Complexes that display sequence specific binding will be targeted. The use of such complexes as DNA cleaving reagents will also be pursued. These studies will be carried out using a variety of techniques such as absorption and emission spectroscopy, DNA melting experiments, ITC, and SPR. Further studies will use plasmid DNA as a substrate for photocleavage experiments.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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