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1-deoxy-D-xylulose 5-phosphate reductoisomerase as a potential novel target for antimicrobial development
Reference
B17965
Principal Investigator / Supervisor
Professor Russell Cox
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
185,660
Status
Completed
Type
Research Grant
Start date
17/02/2003
End date
17/02/2006
Duration
36 months
Abstract
The enzyme 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase (DXP-R) plays a key role in bacterial terpene biosynthesis. Genetic deletion of this enzyme is lethal, so inhibitors of DXP-R could be expected to be excellent antibacterials. Since mammals do not use this enzyme, inhibitors of DXP-R should possess intrinsically low toxicity to humans. We aim to investigate this enzyme by synthesising its natural substrate, setting up an activity assay and then investigating its mechanism. We will also investigate the synthesis of a range of possible inhibitory lead compounds with the aim of developing a new, non-natural-product based, class of antibacterial compounds. The synthetic methods developed will be applicable to the synthesis of a wide range of potential inhibitors and potential new antibacterial compounds.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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