Award details

An NMR study of human serum retinol-binding protein: sequence conservation folding and the molten globule state

Reference	B17889
Principal Investigator / Supervisor	Professor Christina Redfield
Co-Investigators / Co-Supervisors	Dr Lesley Greene, Professor Peter Hore, Professor Lorna Smith
Institution	University of Oxford
Department	Oxford Chemistry
Funding type	Research
Value (£)	121,542
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	30/09/2004
Duration	24 months

Abstract

Human serum retinol-binding protein (RBP) is a member of the lipocalin superfamily of beta-barrel proteins. In this project NMR spectroscopy will be used to study the folding process and the partially folded molten globule state of RBP. The overall aims of this project are: (1) To determine if a relationship exists in RBP between residues which form the core in the kinetic folding intermediate, residues which stabilise the structure of the low pH molten globule and the evolutionarily conserved residues identified in the lipocalin superfamily. (2) To understand the role of the molten globule of RBP in the release of the retinol ligand.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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