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Peptide-based inhibitors for the phosphoinositide phosphatases

Reference	B17388
Principal Investigator / Supervisor	Professor Robin Leatherbarrow
Co-Investigators / Co-Supervisors	Dr Piers Gaffney, Professor Alethea Tabor, Dr Rudiger Woscholski
Institution	Imperial College London
Department	Chemistry
Funding type	Research
Value (£)	249,644
Status	Completed
Type	Research Grant
Start date	13/01/2003
End date	12/05/2006
Duration	40 months

Abstract

Phosphoinositide (PI) signalling is of utmost importance for cellular function and ultimately human health. Specific inhibitors (e.g. wortmannin, LY294002) of PI 3-kinases have greatly facilitated the demonstration that these enzymes are essential regulators of cell growth, survival and development. However, PI phosphatase research lacks specific inhibitors. We are proposing to create a peptide-based PI phosphatase inhibitors using a novel approach amalgamating combinatorial peptide and inositol chemistry, which will ultimately allow us to inhibit specific PI phosphatases in a cellular system.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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