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Structural analysis of the DNA translocation system in a double-stranded DNA bacteriophage
Reference
B17360
Principal Investigator / Supervisor
Professor Elena Orlova
Co-Investigators /
Co-Supervisors
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
211,524
Status
Completed
Type
Research Grant
Start date
04/10/2002
End date
03/07/2006
Duration
45 months
Abstract
Viruses are highly robust protein-nucleic acid complexes that resist environmental insult, but are dynamic enough to efficiently deliver the viral chromosome upon interaction with a target host cell. Using cryo- electron microscopy and single particle analysis, we have been studying the complexes involved in DNA packaging in the Bacillus subtilis bacteriophage SPP1. Here we propose to determine structure of the bacteriophage tail-connector and tail-spike complexes that are involved in DNA translocation during infection of the host cell. The structures determined will allow us to analyse conformational changes during self-assembly by comparison with other states and by fitting the atomic structures of known components in the EM density maps.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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