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Functional and structural dissection of hemicellulose degradation

Reference	B17323
Principal Investigator / Supervisor	Professor Gideon Davies
Co-Investigators / Co-Supervisors	Professor Harry Gilbert
Institution	University of York
Department	Chemistry
Funding type	Research
Value (£)	231,840
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	30/09/2005
Duration	36 months

Abstract

Hemicelluloses are a structurally and chemically diverse array of polysaccharides in which the backbone is not only decorated with a large spectrum of functional groups but also features both glycosidic and ester linkages. This chemical heterogeneity poses a greater challenge for the enzymatic catalysts, which degrade the substrates. Recent genomic data reveal the complexity of the enzymatic consortia that are utilised for this task in nature. The objective of this programme is to harness structural biology, biophysics and enzymology to study key hemicellulose degrading enzymes. The dissection of how these biocatalysts target specific bonds within these highly complex polysaccharides, will provide important insights into carbohydrate-protein recognition and catalysis and will build a framework for the continuing exploitation of these enzymes as environmentally-friendly catalysts.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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