Award details

Towards high throughput high quality macromolecular crystal structure solutions

Reference	B17320
Principal Investigator / Supervisor	Professor Keith Wilson
Co-Investigators / Co-Supervisors	Professor Kevin Cowtan, Professor Eleanor Dodson, Dr Garib Murshudov
Institution	University of York
Department	Chemistry
Funding type	Research
Value (£)	499,116
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	30/11/2005
Duration	38 months

Abstract

For maximum utility and effectiveness, the Rapid Generic Expression Systems (RAGES) must yield high quality structural information. Structures are now often being determined by scientists inexperienced in protein crystallography. There is a danger that this will limit productivity, and degrade the quality of information deposited in the databases. This proposal aims to automate the computational aspects of the structure solution process. Scripting will link the various stages in the analysis, and better algorithms will be formulated in three key problem areas: (i) molecular replacement, (ii) generation of atomic models, and (iii) quality assessment.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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