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A computational investigation of G-protein coupled receptor dimerisation
Reference
B17252
Principal Investigator / Supervisor
Professor Christopher Reynolds
Co-Investigators /
Co-Supervisors
Institution
University of Essex
Department
Biological Sciences
Funding type
Research
Value (£)
128,100
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
28/02/2005
Duration
24 months
Abstract
GPCR dimerization and heterodimerization and highly significant phenomena in signal transduction that have wide-ranging implications for many areas of research, particularly in the pharmaceutical industry. Despite a high level of international activity, including a small but highly significant UK contribution, the significance of GPCR dimerization for activity is not understood at the molecular level. Here we propose to investigate GPCR dimerization at the molecular level through a range of computational activities including bioinformatics and simulation. These studies will draw heavily on very recent biophysical, mutational and drug-binding data that permit key studies on the nature of the active receptor, the nature of the dimer and insig.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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