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Comparative structural biology and chemistry of novel crotonases
Reference
B17227
Principal Investigator / Supervisor
Professor Gideon Grogan
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
135,936
Status
Completed
Type
Research Grant
Start date
01/09/2002
End date
01/09/2004
Duration
24 months
Abstract
The three dimensional structure of 6-oxo camphor hydrolase, OCH, a new member of the crotonase superfamily and a novel biocatalyst for asymmetric retro-Claisen reactions, will be determined by X-ray crystallography. The molecular structural bases for substrate recognition, enantioselectivity and catalysis will be studied with the aid of site-directed mutants. A comparison of the chemistry and biology of OCH with crotonases of known and unknown mechanism and structure will focus on their divergent catalytic chemistries, with particular reference to Coenzyme-A binding and the catalytic fidelity of superfamily members. The implications of this study for further use of crotonases in cofactor independent biocatalysis will be assessed.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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