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NMR studies of real-time protein folding quantum information processing and plant metabolic flux

Reference	B17210
Principal Investigator / Supervisor	Professor Peter Hore
Co-Investigators / Co-Supervisors	Dr Steven Hill, Professor Jonathan Jones, Dr Nicholas Kruger, Professor Richard Ratcliffe, Professor Lorna Smith
Institution	University of Oxford
Department	Oxford Chemistry
Funding type	Research
Value (£)	1,174,548
Status	Completed
Type	Research Grant
Start date	01/02/2003
End date	30/06/2007
Duration	53 months

Abstract

A 600 MHz nuclear magnetic resonance (NMR) spectrometer will be shared equally by three independent research groups. Real-time stopped-flow NMR and CIDNP (Chemically Induced Dynamic Nuclear Polarisation) methods will be developed and used to characterise transient intermediates in protein folding. NMR techniques will be used to construct and investigate simple quantum information processing devices, and to develop new approaches for use in large-scale quantum computers. Plant metabolic fluxes will be studied by: (i) using NMR analyses of steady-state, stable isotope labelling experiments to quantify fluxes in maize roots and Arabidopsis cells; and (ii) developing NMR methods to measure carbon fluxes and to test metabolic hypotheses in purified plant mitochondria.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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