Award details

The molecular basis of the regio- and stereochemical specificity of sesquiterpene cyclases

Reference	B17177/2
Principal Investigator / Supervisor	Professor Rudolf Allemann
Co-Investigators / Co-Supervisors
Institution	Cardiff University
Department	Chemistry
Funding type	Research
Value (£)	78,118
Status	Completed
Type	Research Grant
Start date	01/03/2005
End date	31/12/2005
Duration	10 months

Abstract

Terpene cyclases catalyse the remarkably complex cyclisations of isoprenoid pyrophosphates with remarkable regio- and stereospecificity. The products serve a wide variety of biological functions and some act as antimicrobials or anti-cancer agents. Sesquiterpene cyclases maximise product diversity from a single substrate (FPP). Interestingly, many plant sesquiterpene cyclases share a protein fold and have active sites of similar architecture. We will use a combination of structural analysis of sesquiterpene cyclases by X-ray crystallography and mechanistic studies to decipher the molecular basis of the exquisite specificity of this family of structurally related proteins, ultimately leading to the production of novel terpenes with potential applications as pharmaceuticals and agrochemicals.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B17177 The molecular basis of the regio- and stereochemical specificity of sesquiterpene cyclases

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search