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The effects of specific protein-lipid interactions on the stability of an integral membrane protein

Reference	B17125
Principal Investigator / Supervisor	Professor Mike Jones
Co-Investigators / Co-Supervisors	Professor Peter Heathcote
Institution	University of Bristol
Department	Biochemistry
Funding type	Research
Value (£)	170,088
Status	Completed
Type	Research Grant
Start date	12/08/2002
End date	12/08/2005
Duration	36 months

Abstract

In recent years it has shown that integral membrane proteins make specific interactions with membrane lipids. The relationship between the strength and number of these interactions and the thermal stability of an integral membrane protein will be examined. A new binding site for a membrane lipid will be engineered on the surface of the Rhodobacter sphaeroides reaction centre, and specific proposals that the enhanced thermal stability of the Thermochromatium tepidum reaction centre is due to an increased number of surface exposed arginine residues will be tested. EPR spectroscopy will be used to examine the affinity of the Rhodobacter sphaeroides reaction centre for specific lipids, in wild type and mutant complexes.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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