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Award details
Folding active site and mechanism of the VS ribozyme
Reference
B17092
Principal Investigator / Supervisor
Professor David Lilley
Co-Investigators /
Co-Supervisors
Dr David Norman
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
371,048
Status
Completed
Type
Research Grant
Start date
01/01/2003
End date
31/01/2007
Duration
49 months
Abstract
Ribozymes provide an excellent opportunity to study biocatalysis in a simplified molecular environment, and the motivation behind the work proposed in this grant is to gain an understanding of the mechanistic origins of the nucleolytic ribozyme VS of Neurospora. We have made considerable progress with this ribozyme in the last 3 years, in terms of deducing the overall RNA fold and identifying the active site. We now propose to advance our understanding of the VS ribozyme. This work will include further studies of the structure and folding of the RNA, and detailed mechanistic studies of the catalysis.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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