Award details

The influence of membranes on protein stability

Reference	B17005
Principal Investigator / Supervisor	Dr Leo Lue
Co-Investigators / Co-Supervisors	Dr James Warwicker
Institution	The University of Manchester
Department	Chem Eng and Analytical Science
Funding type	Research
Value (£)	186,044
Status	Completed
Type	Research Grant
Start date	07/10/2002
End date	07/10/2005
Duration	36 months

Abstract

Protein-membrane interactions play a major role in many biological systems. We intend to study how the presence of a membrane influences the structure of a protein. Lattice protein simulations will be performed to examine the general conditions under which proteins unfold (or fold) and absorb when brought in proximity of a membrane. Incorporating the insights gained from the lattice simulation studies, we will develop continuum modelling of membrane-protein interactions, and validate this approach against the lattice simulation data and with reference to the behaviour of cytochrome c (cyt c), retinol-binding protein (RBP), and barnase.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search