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Interactions and assembly of components of the type III secretion apparatus from Yersinia
Reference
B16990
Principal Investigator / Supervisor
Dr Katherine Brown
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
392,556
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
31/12/2005
Duration
48 months
Abstract
The bacterial type III secretion apparatus is a complex multicomponent system composed of approximately 20 inner and outer membrane proteins. This apparatus can form a molecular syringe which allows proteins to be delivered from a pathogenic bacterium directly into a eukaryotic cell as part of the infection process, often inactivating primary host defence systems. A highly integrated biophysical approach will be undertaken to characterise structures and assembly processes of the prototypical type III secretion systems of Yersinia. Complementary cell-based assays will be used to study mutants designed to perturb protein-protein interactions to better understand the functional role of these assemblies in vivo. Work will focus initially on the LcrV and LcrG proteins with a view to extending these studies to other type III components.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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