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Modes of action of epipolythiopiperazine-2 5-diones (ETPs): DNA cleavage and proteasomal interactions
Reference
B16703
Principal Investigator / Supervisor
Professor William B Motherwell
Co-Investigators /
Co-Supervisors
Professor David Selwood
Institution
University College London
Department
Chemistry
Funding type
Research
Value (£)
127,952
Status
Completed
Type
Research Grant
Start date
08/04/2002
End date
08/04/2004
Duration
24 months
Abstract
Epipolythiopiperazine-2,5-diones (ETPs) are a diverse group of natural products with a range of biological activities. Gliotoxin is known to inhibit NF-kappaB by blocking the action of the proteasome on I kappa Balpha. These agents can also cleave DNA in vitro. The sulphur bridge in ETPs is known to be essential for ETP activity but its mode of action is unknown. In this project the mechanisms of these activities will be established through both biochemical experiments and by utilising novel ETPs to explore the relationship of ETP structure to the observed biological activity. The involvement of unusual thiyl radicals in these activities will be investigated.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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