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Molecular mechanisms of amino acid recognition by A-domains of the Streptomyces coelicolor A3(2) coelichelin NRPS
Reference
B16610
Principal Investigator / Supervisor
Professor Gregory Challis
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Chemistry
Funding type
Research
Value (£)
182,084
Status
Completed
Type
Research Grant
Start date
01/08/2002
End date
31/07/2006
Duration
48 months
Abstract
Non-ribosomal peptide synthetases (NRPSs) are a large family of modular multienzymes that catalyse the biosynthesis of many commercially important microbial natural products. Adenylation (A) domains within each NRPS module selectively bind and activate (by reaction with ATP) the amino acids constituting the peptide. Structure based models of A-domains have recently been developed, which identify potentially important residues from amino acid recognition and facilitate the prediction of new peptide natural product structures from genome sequence data. The accuracy of these structural predictions and the role played by putative recognition residues will be investigated using the Streptomyces coelicolor A3(2) coelichelin synthetase as a model.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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